Force-close Windows applications when they stop responding and refuse to respond to normal close attempts. Click on Ctrl + Shift + Esc keys to open the Task Manager window. Select the Processes tab from the Task Manager window and find the application that needs to be closed. Select it, then click on “End Task” button. Another way is to right-click on the application on the taskbar and click on “Close window”. This might not work for all programs that have frozen. Another way is to use Alt + F4 key combination.